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TLS Online TPP Program

#Id: 8912

When all the kinetochores have properly attached to spindle microtubules, APC/CCdc20 directs ubiquitinylation of securin and mitotic cyclins

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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TLS Online TPP Program

#Id: 10529

#Unit 4. Cell Communication and Cell Signaling

Annexin V
a 36-kDa calcium-binding protein, binds to PS; used to detect PS that is exposed on the outside of apoptotic cells
TLS Online TPP Program

#Id: 10530

#Unit 4. Cell Communication and Cell Signaling

All members of the Bcl-2 family share a close homology in up to four characteristic regions, termed the Bcl-2 homology domains
TLS Online TPP Program

#Id: 10531

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 10532

#Unit 4. Cell Communication and Cell Signaling

Pro-survival members-
Bcl-2, Bcl-xL, Bcl-w, Mcl-1, A1
TLS Online TPP Program

#Id: 10533

#Unit 4. Cell Communication and Cell Signaling

Pro-apoptotic members form channels in the mitochondrial outer membrane
Bax, Bak, Bok
TLS Online TPP Program

#Id: 10534

#Unit 4. Cell Communication and Cell Signaling

BH3-only proteins: Regulate activity of Bcl-2 and Bax/Bak proteins
Bim, Puma, Noxa, Bik, Bmf, Bad, Hrk, Bid