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TLS Online TPP Program

#Id: 9363

Phosphorylation of two serines in Ser-X-Ser motif at the extreme C-terminus of the MH2 domain by the activated RI separates the two domains, exposing the NLS for binding to importins

#Unit 4. Cell Communication and Cell Signaling #TGF-β Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 1716

#Unit 4. Cell Communication and Cell Signaling

The serum half-life of IgE is quite short (only 2 to 3 days). However, when bound to its receptor on an innate immune cell, IgE is stable for weeks.
TLS Online TPP Program

#Id: 7879

#Unit 2. Cellular Organization

The curvature of the crista junctions is due to a protein complex called MICOS (mitochondrial contact site and cristae organizing system).
TLS Online TPP Program

#Id: 8337

#Unit 2. Cellular Organization

Profilin – G-actin nucleotide exchange (ADP to ATP) 
Cofilin – F-actin disassembly
Thymosin B-4 – G-actin monomer sequestering
TLS Online TPP Program

#Id: 5524

#Unit 10. Ecological Principles
TLS Online TPP Program

#Id: 3648

#Unit 3. Fundamental Processes

In ValRS, the side chain of Asp 279 protrudes into the editing active site, where it hydrogen-bonds with the hydroxyl group of threonine. The isosteric (having the same shape) valine lacks this hydroxyl group and is thereby excluded from the editing pocket.