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TLS Online TPP Program

#Question id: 14969

 A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 2. Cellular Organization
  1. We should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.
  2. We should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.
  3. We should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.
  4. We should abandon the drug entirely binding to lipid A won't kill the bacteria, so the drug is useless to develop further
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TLS Online TPP Program

#Question id: 19117

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
 
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 2.
TLS Online TPP Program

#Question id: 19118

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                               
Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 1.
TLS Online TPP Program

#Question id: 19119

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                     
Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 2.
TLS Online TPP Program

#Question id: 19120

#Unit 8. Inheritance Biology

Trisomy 18 is one of the most common trisomies observed in human populations. You prepare DNA samples from two unrelated infants, both with trisomy 18, and from their parents. You then type the infants and their parents for four SSRs distributed along chromosome 18:
 

                                      
In which parent did nondisjunction occur in Family 1?
TLS Online TPP Program

#Question id: 19121

#Unit 8. Inheritance Biology

Trisomy 18 is one of the most common trisomies observed in human populations. You prepare DNA samples from two unrelated infants, both with trisomy 18, and from their parents. You then type the infants and their parents for four SSRs distributed along chromosome 18:
 

                                              
In which parent did nondisjunction occur in Family 2?
TLS Online TPP Program

#Question id: 19122

#Unit 8. Inheritance Biology

Trisomy 18 is one of the most common trisomies observed in human populations. You prepare DNA samples from two unrelated infants, both with trisomy 18, and from their parents. You then type the infants and their parents for four SSRs distributed along chromosome 18:
     
             
                                         
In which division of meiosis did nondisjunction occur in Family 2?