we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

TLS Online TPP Program

#Question id: 27090

#Unit 1. Molecules and their Interaction Relevant to Biology

Steroids receptor are

TLS Online TPP Program

#Question id: 28491

#Unit 5. Developmental Biology

A major active factor in the Progressive zone is___

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#Question id: 16780

#Unit 13. Methods in Biology

Find the Median of the following grouped data. 

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#Question id: 30105

#Unit 1. Molecules and their Interaction Relevant to Biology

Methotrexate is an inhibitor of dihydrofolate reductase. Administration of methotrexate would inhibit:

1. de novo synthesis of UMP.

2. conversion of dUMP to dTMP.

3. conversion of IMP to GMP.

4. de novo synthesis of IMP

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#Question id: 18586

#Unit 7. System Physiology – Animal

Letting go of accumulated muscle stiffness and tension is the focus of this relaxation technique ______.