TLS Online TPP Program

#Question id: 290


Which of the following is a TRUE statement about ionic bonds in protein structure:

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. Ionic bonds on the external surface of the folded protein are more stable than those buried in the protein interior.

  2. In an ionic bond, a hydrogen atom carrying a partial positive charge on the electronegative atom of one covalent bond interacts with the partial negative charge of an electronegative atom of a second polar covalent bond.

  3. Ionic bonds can only form between acidic and basic polar charged amino acid R groups in a specific pH range.

  4. Ionic bonds only exist in inorganic molecules.

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TLS Online TPP Program

#Question id: 4284

#Unit 3. Fundamental Processes

Assays for following the trafficking of proteins through the secretory pathway in living cells require

a. sensitive methods to distinguish the very small differences in organelle density caused by passage of a wave of protein transport through the organelle.

b. a way to identify compartments where labeled proteins are located.

c. the use of cell types that are highly dedicated secretory cells.

d. the use of enucleate cells in order to eliminate the nucleus as a site of labeling.

e. a way to label a cohort of secretory proteins

TLS Online TPP Program

#Question id: 4285

#Unit 3. Fundamental Processes

VSV G protein has been a very useful tracker protein for both living cell and in vitro assays because

TLS Online TPP Program

#Question id: 4286

#Unit 3. Fundamental Processes

Transport vesicles

a. can have a clathrin coat.     b. can be coated with a heteromeric COPI and COPII coat.

c. can contain assembly proteins.

d. can shuttle proteins from mitochondria to the endoplasmic reticulum.

e. can fuse with target organelles.

TLS Online TPP Program

#Question id: 4287

#Unit 3. Fundamental Processes

How the mTOR pathway increases the protein synthesis?

TLS Online TPP Program

#Question id: 4288

#Unit 3. Fundamental Processes

During eukaryotic protein synthesis, stress conditions result in activation of specific kinases leading to phosphorylation of a key translation initiation factor that inhibits protein synthesis from a large number of cellular mRNA. Which one of the following factors is the kinase?

TLS Online TPP Program

#Question id: 4289

#Unit 3. Fundamental Processes

Match the Following

A. fidelity of codon recognition

1. involves two adjacent adenine residues in the 16S rRNA component located

within the A-site of the small subunit. These bases form hydrogen bonds with

the minor groove of each correct base pair formed between the anticodon and

the first two bases of the codon in the A-site

B. kinetic selectivity

2. Even a single mismatch in the codon–anticodon base pairing alters the position of EF-Tu, reducing its ability to interact with the factor-binding center. This, in turn, leads to a dramatic reduction in EF-Tu GTPase activity

C. Accommodation

3. When the charged tRNA is first introduced

into the A-site in a complex with EF-Tu-GTP, its 30 end is distant from the site of peptide-bond formation. To participate successfully in the peptidyl transferase reaction, the tRNA must rotate into the peptidyl transferase center of the large subunit in a process