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#Question id: 2881


Depletion of a 2.2-kb noncoding RNA expressed from the HOXC locus by siRNA unexpectedly led to derepression of the HOXD locus on another chromosome encoding several Hox proteins and multiple other noncoding RNAs, in these cells. Assays similar to chromatin immunoprecipitation showed that this noncoding RNA, named HOTAIR, associates with the HOXD loci and with PRC2 complexes. This association results in

i. Histone H3K9 di- and trimethylation

ii. H2B monoubiquitinylation

iii. Histone H3K4 demethylation

iv. H2A monoubiquitinylation

v. Histone H3K4 methylation

vi. Histone H3K27 di- and trimethylation

Which of the following results is CORRECT regarding this association?

#Unit 2. Cellular Organization
  1. i, ii and iii

  2. i, iii and iv

  3.  iii, iv and vi

  4. ii, v and vi

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TLS Online TPP Program

#Question id: 5727

#Unit 8. Inheritance Biology

Pairing occurs during the prophase of meiosis I, after the chromosomes have been duplicated. Centromere mention as 1, 2, 3 and 4

Which of the following is correct statement Types of disjunction in a translocation heterozygote during meiosis I.

A) Centromeres 1 and 3 go to one pole and centromeres 2 and 4 go to the other pole, producing non fuctional gametes.

B) Centromeres 1 and 2 go to one pole and centromeres 3 and 4 go to the other pole, producing viable gametes.

C) Centromeres 2 and 3 go to one pole and centromeres 1 and 4 go to the other pole, producing euploid gametes.

D) Centromeres 2 and 3 go to one pole and centromeres 1 and 4 go to the other pole, producing non viable gamete

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#Question id: 5728

#Unit 8. Inheritance Biology

A phenotypically normal man carries a translocated chromosome that contains the entire long arm of chromosome 14, part of the short arm of chromosome 14, and most of the long arm of chromosome 21. The man also carries a normal chromosome 14 and a normal chromosome 21. If he marries a cytologically (and phenotypically) normal woman, there is many chance that the couple will produce phenotypically abnormal children? Which of the following is correct combination?

TLS Online TPP Program

#Question id: 5729

#Unit 8. Inheritance Biology

One chromosome in a plant has the sequence A B C D E F, and another has the sequence M N O P Q R. A reciprocal translocation between these chromosomes produced the following arrangement: A B C P Q R on one chromosome and M N O D E F on the other. If an individual is heterozygous for this translocation, the consequence in meiosis will be as follows:    

A. The two normal chromosomes and-two translocated chromosomes pair separately

B. Half of gametes produced from this meiosis are non-viable as they have deletions and duplications

C. In one of the cross configurations called "horizontal segregation" all gametes having normal or translocated chromosomes will not survive

D. The gametes having normal chromosomes only survive while all gametes having translocated chromosomes are non-viable, hence the translocations are used as crossover suppressors

Which of the following combinations best describes the meiotic consequences for the translocation described above?

TLS Online TPP Program

#Question id: 5730

#Unit 8. Inheritance Biology

In a family, father is homozygous dominant (AA) for a gene A and his wife is homozygous for its ressive allele (aa) showing albino phenotype. It was surprising that their child showed the albino phenotype. Which of the following phenomenon can explain the phenotype?

TLS Online TPP Program

#Question id: 5731

#Unit 8. Inheritance Biology

If an individual is heterozygous for this translocation, the consequence in meiosis will be as follows:

A) Segregation results in a + c in one Gametes and b + d in another gametes, have duplication and deficiency so unable to produce viable offspring

B) Segregation results in a + b in one Gametes and c + d in another gametes, have normal chromosome so all viable offspring produced

C) Segregation results in a + d in one Gametes with normal chromosome and b + c in another gametes contains translocation arrangement, all viable offspring produced

D) Segregation results in a + d in one Gametes with normal chromosome, will produced viable offspring while b + c in another gametes contains translocation arrangement, will produce non viable offspring.

TLS Online TPP Program

#Question id: 5732

#Unit 8. Inheritance Biology

Consider a plant, such as maize, heterozygous for a paracentric inversion. The inversion is very small and a synapsed inversion loop does not occur in any of the cells. Which of the following statement is correct?