TLS Online TPP Program

#Question id: 2881


Depletion of a 2.2-kb noncoding RNA expressed from the HOXC locus by siRNA unexpectedly led to derepression of the HOXD locus on another chromosome encoding several Hox proteins and multiple other noncoding RNAs, in these cells. Assays similar to chromatin immunoprecipitation showed that this noncoding RNA, named HOTAIR, associates with the HOXD loci and with PRC2 complexes. This association results in

i. Histone H3K9 di- and trimethylation

ii. H2B monoubiquitinylation

iii. Histone H3K4 demethylation

iv. H2A monoubiquitinylation

v. Histone H3K4 methylation

vi. Histone H3K27 di- and trimethylation

Which of the following results is CORRECT regarding this association?

#Unit 2. Cellular Organization
  1. i, ii and iii

  2. i, iii and iv

  3.  iii, iv and vi

  4. ii, v and vi