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TLS Online TPP Program

#Question id: 2882

SUMO (small ubiquitin-related modifier) proteins are ∼10-kD polypeptides that function as reversible post-translational protein modifiers. They form isopeptide bonds with ɛ-amino groups of acceptor Lys residues in hundreds of target proteins in a process termed as sumoylation. Which of the following statements is correct regarding this modification?

#Unit 2. Cellular Organization

  1. A short non-covalent SUMO-interaction/binding motif (SIM/SBM) has been identified in all SUMO enzymes, targets and downstream effectors. This motif contributes to the mechanism and consequences of sumoylation.

  2. Acceptor Lys residues in target proteins are frequently found in the consensus motif ΨKxD although the number of targets with non-consensus acceptor sites is steadily increasing.

  3. Irreversible sumoylation contributes to many distinct pathways, such as chromatin structure, DNA repair, transcription, cell-cycle progression and trafficking.

  4. Sumoylation alters the molecular interactions of modified target proteins by masking or adding interaction surfaces. Downstream consequences, which are target dependent, include changes in localization, activity and protein stability.

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TLS Online TPP Program

#Question id: 28309

#Unit 5. Developmental Biology

Which of the following chemotactic factor is secreted by oocyte and its cumulus cells that involve to attract capacitated sperm toward the egg during the last stages of sperm migration?
TLS Online TPP Program

#Question id: 28310

#Unit 5. Developmental Biology

In case of mouse cumulus cells secrete a substance that attracts sperm and hyperactivates them through CatSper channels, these substance is___ 
TLS Online TPP Program

#Question id: 28311

#Unit 5. Developmental Biology

zona pellucida is made of glycoproteins, Which of the following zona pellucida or ZP protein is differentiating between mouse and human?  
TLS Online TPP Program

#Question id: 28312

#Unit 5. Developmental Biology

 Mammalian egg have pathways for accepting both (heterogeneous population) types of capacitated sperm acrosome-intact sperm as well as acrosome-reacted sperm, sperm with intact acrosomes become bound to ___
TLS Online TPP Program

#Question id: 28313

#Unit 5. Developmental Biology

During acrosome-reacted sperm pathway sperm that have undergone the acrosome reaction bind directly to which of the glycoprotein?
TLS Online TPP Program

#Question id: 28314

#Unit 5. Developmental Biology

Mammalian egg have pathways for accepting both types of capacitated sperm acrosome-intact sperm as well as acrosome-reacted sperm pathway ultimately lead to the activation of acrosomal reaction that proceed by acrosomal protein. these important acrosomal proteins are____