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TLS Online TPP Program

#Question id: 2901

HOTAIR is a lncRNA whose gene is found in the HoxC cluster in humans, but it acts by regulating expression of the HoxD genes on another chromosome (in trans) by recruiting to that locus Polycomb Repressive Complex 2 (PCR2). Which of the following processes is incorrect regarding this regulation?

#Unit 2. Cellular Organization

  1. PRC2 adds trimethyl groups to lysine 9 of histone H3, a mark (H3K9me3) associated with repressed gene expression.

  2. HOTAIR also recruits a second complex that removes histone modifications typically associated with active genes.

  3. HOTAIR has also been found to be up-regulated in some cancers. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.

  4. HOTAIR never found to be up-regulated in some cancers. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.

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TLS Online TPP Program

#Question id: 26518

#Unit 3. Fundamental Processes

A significant difference between the transcription of eukaryotic and prokaryotic RNAs is, choose the correct option
a.In bacteria, transcription takes place on a DNA template
b.In bacteria takes place on a chromatin template as a domain 
c.In eukaryotes, transcription takes place on a chromatin template as a domain 
d.In eukaryotes transcription takes place on a DNA template
TLS Online TPP Program

#Question id: 26519

#Unit 3. Fundamental Processes

A regulatory site that binds more negative regulators than positive regulators to control transcription is called a
TLS Online TPP Program

#Question id: 26520

#Unit 3. Fundamental Processes

RNA polymerase I synthesizes rRNA in the
TLS Online TPP Program

#Question id: 26521

#Unit 3. Fundamental Processes

Eukaryotic RNA Pol and No. of subunits are given match them correctly

 Eukaryotic RNA Pol No. of subunits 
 1. RNA Pol I a. 12 subunits
 2. RNA Pol II b. 17 subunits
 3. RNA Pol III c. 14 subunits
TLS Online TPP Program

#Question id: 26522

#Unit 3. Fundamental Processes

Rpo I has =14 subunits, Rpo II has = 12 subunits, Rpo III has = 17 subunits, respectively but There are five common subunits among all these are
TLS Online TPP Program

#Question id: 26523

#Unit 3. Fundamental Processes

Some of the human RNA pol II subunit and features are given, match them correctly

 Subunit Features
 1. hRPB1 a. contains active sites, involved site selection maintain elongation β orthologs
 2. hRPB2 b. contains DNA, Binds DNA Involved site selection, β' orthologs
 3. hRPB3 c. may function as function with Rpb11 as ortholog of the alpha dimer of prokaryotic RNA polymerase