Practice Questions

TLS Online TPP Program

#Question id: 2901

HOTAIR is a lncRNA whose gene is found in the HoxC cluster in humans, but it acts by regulating expression of the HoxD genes on another chromosome (in trans) by recruiting to that locus Polycomb Repressive Complex 2 (PCR2). Which of the following processes is incorrect regarding this regulation?

#Unit 2. Cellular Organization

PRC2 adds trimethyl groups to lysine 9 of histone H3, a mark (H3K9me3) associated with repressed gene expression.
HOTAIR also recruits a second complex that removes histone modifications typically associated with active genes.
HOTAIR has also been found to be up-regulated in some cancers. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.
HOTAIR never found to be up-regulated in some cancers. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.

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TLS Online TPP Program

#Question id: 2004

#Unit 4. Cell Communication and Cell Signaling

A bone marrow transplant may not be appropriate from a given donor (Jane) to a given recipient (Janeʹs cousin Bob), even though Jane has previously given blood for one of Bobʹs needed transfusions. Which of the following might account for this?

TLS Online TPP Program

#Question id: 15761

#Unit 5. Developmental Biology

Which of the following is not a property of stem cell?

TLS Online TPP Program

#Question id: 18822

#Unit 13. Methods in Biology

The PCR variant designed for the study of RNA expression level is

TLS Online TPP Program

#Question id: 26342

#Unit 2. Cellular Organization

Which of the following condition shows polymorphic chromosomes for allele A1 & A2