TLS Online TPP Program

#Question id: 2912


HOTAIR is a lncRNA whose gene is found in the Hox C cluster in humans, but it acts by regulating expression of the Hox D genes on another chromosome (in trans) by recruiting to that locus Polycomb Repressive Complex 2. Which of the following statements is/are correct regarding this regulation?

#Unit 2. Cellular Organization
  1. PRC2 adds trimethyl groups to lysine 27 of histone H3, a mark (H3K27me3) associated with repressed gene expression.

  2. HOTAIR also recruits a second complex that removes histone modifications typically associated with active genes.

  3. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.

  4. All of the above