TLS Online TPP Program

#Question id: 2919


Topoisomerases play the essential role of unlinking the DNA molecules to allow them to separate into the two daughter cells for cell division. Which of the following statements regarding the mechanism of topoisomerases is INCORRECT?

#Unit 2. Cellular Organization
  1. Melting of the DNA strands is favored in highly negatively supercoiled DNA making this DNA an excellent substrate for relaxation.

  2. This product DNA is identical to the starting DNA molecule, except that the linking number has been increased by 1.

  3. Topoisomerase function requires that DNA cleavage, strand passage, and DNA rejoining all occur in a highly coordinated manner.

  4. The OH group from one broken DNA end attacks the phospho-tyrosine bond re-forming the DNA phosphodiester bond via ATP hydrolysis.