Following statements regarding to noncanonical wnt pathways.

A. The planar cell polarity, or PCP, pathway functions to regulate the actin and microtubule cytoskeleton, thus influencing cell shape, and often results in bipolar protrusive behaviors necessary for a cell to migrate.

B. Wnts (such as Wnt5a and Wnt11) can activate Disheveled by binding to a different receptor (Frizzled paired with Ror instead of Lrp5), and this Ror receptor complex phosphorylates Disheveled in a way that allows it to interact with Rho GTPases.

C. Wnt/PCP signaling through cytoskeleton control can direct cells to divide in the different plane ( forming upper and lower tissue compartments) and to move within that different plane.

D. the Wnt/calcium pathway leads to the release of calcium stored within cells, and this released calcium acts as an important secondary messenger to activates a phospholipase (PLC) whose enzyme activities release a compound that in turn releases calcium ions from the cytosol.

Which of the following is incorrect?

TLS Online TPP Program

#Question id: 14885

#Unit 4. Cell Communication and Cell Signaling

Mature T cell is found in thymus in

TLS Online TPP Program

#Question id: 14886

#Unit 4. Cell Communication and Cell Signaling

Secondary lymphoid organ provide sites where lymphocytes encounter antigen, become activated, and undergo clonal expansion and differentiation into effector cells, include

a) spleen

b) lymph node

c) mucosa-associated lymphoid tissue

Which of the following are the effector cells of secondary lymphoid organ?

TLS Online TPP Program

#Question id: 14887

#Unit 4. Cell Communication and Cell Signaling

Secondary lymphoid organ are typically compartmentalized into T-cell areas and B-cell areas, these cells activity are separated  into distinct microenvironments such as

a) T cells are found in the paracortex of the lymph nodes

b) B cells are organized into follicles cells

c) B cells are found in the periarteriolar sheath of the spleen.

d) T cells are found in the periarteriolar sheath of the spleen.

Which of the following is the correct microenvironments of the cells ?

TLS Online TPP Program

#Question id: 14888

#Unit 4. Cell Communication and Cell Signaling

Given below are some cytokines and stimulated cell lines ;

CYTOKINE	CELL LINES STIMULATED
A) IL-1	i) Basophils
B) IL-4	ii) Myeloid lineages
C) IL-5	iii) Platelets
D) IL-6	iv) Megakaryocyte
E) Thrombopoietin	v) Eosinophill

Which one of the following is the correct match between the Interleukines and cell lines ?

TLS Online TPP Program

#Question id: 14889

#Unit 4. Cell Communication and Cell Signaling

If we provide  the Ikaros signals to the HSCs cell  is converted into

TLS Online TPP Program

#Question id: 14890

#Unit 4. Cell Communication and Cell Signaling

In bone marrow, stem cells are committed to different lineages. Factors that stimulate colonies of these different lineages are interleukin-3 granulocyte- macrophage colony stimulating factor (GM-CSF)

A) Granulocyte colony stimulating factor ( G-CSF )and 

B) Macrophage colony- stimulating factor (M-CSF) are formed;

i) Natural killer cells

ii) Monocytes

iii) Granulocytes

iv) Neutrophills

Find out the correct combination of these macrophages;