Cyclin-dependent kinases (CDK) belongs to which family of kinases?

#Question id: 7236

#Unit 5. Developmental Biology

Which of the following statement justified that the PMZ in chick is functionally equivalent to the amphibian Nieuwkoop center?

A. The posterior marginal zone produces Wnt8c and that, the PMZ cells secrete Vg1, a member of the TGF-β family.

B. PMZ cells capable of inducing the accumulation of β-catenin

C. PMZ cells secretes BMP, a member of the TGF-β family.

D. PMZ secretes its own Nodal antagonist—the Lefty protein.

Which of the following combination is correct?

#Question id: 7237

#Unit 5. Developmental Biology

Following statements were made regarding vulval development in C. elegans:

A. The formation of the anchor cell is mediated by lin-12, the C. elegans homologue of the Notch gene.

B. The formation of the anchor cell is mediated by lin-12, the C. elegans homologue of the Delta gene.

C. The lin-12 gene needs to function only in that cell destined to become the uterine precursor cell.

D. Presumptive Anchor cell also need lin-12.

E. Two cells originally synthesize both the signal for uterine differentiation (the LAG-2 protein, homologous to Delta) and the receptor for this molecule (the LIN-12 protein, homologous to Notch.

F. Only one cell synthesize both the signal for uterine differentiation (the LAG-2 protein, homologous to Delta) and the receptor for this molecule (the LIN-12 protein, homologous to Notch.

Which one of the following options represents a combination of incorrect statements?

#Question id: 7238

#Unit 5. Developmental Biology

Following are the statements regarding to establishment of positive feedback loops for limb bud formation.

A. In the presumptive forelimb field, Tbx5 induces Wnt2b, which then upregulates Fgf10, which in turn positively feeds back to maintain activation of both Wnt2b and Tbx5.

B. Mesodermal Fgf10 tells the surface ectoderm to continue to make Fgf8, and the surface ectoderm continues to tell the underlying mesoderm to make Fgf10.

C. Fgf10 provides the signal to initiate and propagate the limb-forming interactions between ectoderm and mesoderm, and these signaling interactions directly promote limb bud formation and growth.

D. The Wnt protein acts through the canonical β-catenin pathway to induce Fgf8 expression in the ectoderm. This relay of signaling represents a foundational stage in the formation of limb buds, because once Fgf8 is made in the surface ectoderm, the surface ectoderm elongates to physically become the AER.

Which of the following statements correctly explained positive feedback loops during limb development?

#Question id: 7239

#Unit 5. Developmental Biology

C. elegans embryo uses both autonomous and conditional modes of specification. Conditional specification at the 4-cell stage can be seen in the development of the endoderm cell lineage and also in the establishment of dorsal-ventral axis. Following are few statements regarding this figure:

A. If the P2 cell is removed at the early 4-cell stage, the EMS cell will divide into two MS cells and endoderm will be made.

B. In pop-1 deficient embryos, both EMS daughter cells become MS cells.

C. When the position of ABa and ABp was reversed, their fates get reversed and no normal embryo forms.

D. In embryos whose mother have mutant glp-1, ABp is transformed into ABa cell.

Which of the above statements are true?

#Question id: 7240

#Unit 5. Developmental Biology

Given below are the list of some organism (column A) and determination of their dorsal-ventral axis (column B)

 Choose the correct option:

#Question id: 7241

#Unit 5. Developmental Biology

If planaria are irradiated at a dosage that destroys nearly all neoblasts. Transplanting a single clonogenic neoblast in this planaria results: