TLS Online TPP Program

#Question id: 31376


In S. cerevisiae, DNA replication is tightly controlled, and DNA should replicate once per cell cycle. Choose the INCORRECT statement regarding why the cells do not re-replicate their DNA in the S-phase?

#Unit 2. Cellular Organization
  1. Because S phase CDKs phosphorylate several components of the MCM helicase-loading machinery.
  2. Because phosphorylation leads to export of Cdt1 from the nucleus, and degradation of Cdc6 by the SCF ubiquitin-protein ligase in yeast.
  3. Because Cdt1 which helps in the recruitment of MCM proteins in the Gl phase is inactivated by geminin in the S-phase of the cell cycle.
  4. Because MCM helicases are loaded onto DNA to form pre-RCs only when they are phosphorylated.