2-Deoxyglucose (2-DG) inhibits the proliferation of cells and hence finds use as an anti-cancer agent, inhibiting the activities of which of the following enzymes?

TLS Online TPP Program

#Question id: 28698

#Unit 2. Cellular Organization

the oligosaccharide precursor is assembled on a membrane- attached anchor called dolichol phosphate, which is___

TLS Online TPP Program

#Question id: 28699

#Unit 2. Cellular Organization

First sugar residue is attached to dolichol by ___

TLS Online TPP Program

#Question id: 28700

#Unit 2. Cellular Organization

Biosynthesis of all N-linked oligosaccharides begins in the rough ER with a preformed branched oligosaccharide precursor Glc3Man9(GlcNAc)2, Which of the following statements is incorrect about these biosynthesis?

a) the oligosaccharide precursor is assembled on a membrane- attached anchor called dolichol phosphate

b) First sugar residue is attached to dolichol by a glycosidic bonds & the other

sugars are added by high-energy pyrophosphate

c) Two N- acetylglucosamine (GlcNAc) and five mannose residues are added one at a time to a dolichol phosphate on the lumen

d) Four mannose and three glucose  residue are added one to a dolichol phosphate on the luminal side

TLS Online TPP Program

#Question id: 28701

#Unit 2. Cellular Organization

Which of the following inhibitors inhibits the synthesis of all N-linked oligosaccharides in cells?

TLS Online TPP Program

#Question id: 28702

#Unit 2. Cellular Organization

Oligosaccharyl transferase enzyme involves to transferred precursor oligosaccharide 

TLS Online TPP Program

#Question id: 28703

#Unit 2. Cellular Organization

Oligosaccharyl transferase enzyme involves to transferred precursor oligosaccharide from a dolichol lipid anchor to the tripeptide sequences, which of the following tripeptide sequences are substrates for oligosaccharyl transferase ?