TLS Online TPP Program

#Question id: 7160


How does the dose-dependence of retinoic acid treatment support the notion that a gradient of retinoic acid can act as a morphogen along the proximo-distal axis in the limb?

#Unit 5. Developmental Biology
  1. Treatment with high levels of retinoic acid causes a proximal blastema to be respecified as a distal blastema, and only distal structures are regenerated.
  2. Treatment with high levels of retinoic acid causes any blastema to form only distal structures.
  3. Treatment with high levels of retinoic acid causes any blastema to be respecified as a proximal blastema, but it will form only proximal structures.
  4. Treatment with high levels of retinoic acid causes a distal blastema to be respecified as a proximal blastema, and regeneration of a full limb may be initiated from proximal values.