Following statements are related to the Epigenetic regulation of Hox gene expression in the chick limb .

A. Hoxa13 is normally not expressed during early limb bud outgrowth.

B. Hoxa13 is normally expressed during early limb bud outgrowth.

C. Inhibition of histone deacetylases with a TSA-coated bead implanted into the early limb bud results in precocious Hoxa13 expression and specifically reduced skeletal elements of the zeugopod

D. Inhibition of HAT proteins with a TSA-coated bead implanted into the early limb bud results in Hoxa13 expression and specifically reduced skeletal elements of the zeugopod

E. The epigenetic hold on gene Hoxa13 expression to allow the necessary time for zeugopod development.

F. The epigenetic hold on gene Hoxa13 expression to allow the necessary time for autopod development.

Which of the following combinations are correct?

#Question id: 845

#Unit 1. Structure and Function of Biomolecules

The most common cystic fibrosis– causing mutation is the deletion of a Phe residue at position____ in CFTR, which causes improper protein folding

#Question id: 846

#Unit 1. Structure and Function of Biomolecules

The maintenance of the steady-state collection of active cellular proteins required under a particular set of conditions, called ______.

#Question id: 847

#Unit 1. Structure and Function of Biomolecules

A proposed pathway for the action of E.coli chaperonins  are groEL and groES.groEL exist in trans and cis structure transferring with its bound ATP now become the cis ring once the groES  bound to it ATP hydrolysis takes place and improperly folded protein get properly folded, total number of  ATP molecules are required to per folding cycle;

#Question id: 848

#Unit 1. Structure and Function of Biomolecules

Which of the brain diseases is not caused by the misfolding of brain proteins in mammals

#Question id: 849

#Unit 1. Structure and Function of Biomolecules

The rigidity of the peptide unit and the restricted set of allowed phi and psi angles limits the number of structures accessible to the unfolded form sufficiently to allow:-

#Question id: 850

#Unit 1. Structure and Function of Biomolecules

The experimental inverse of protein structure prediction, has provided insights into protein folding and stability. Protein design attempts to construct an amino acid sequence that will form a structure such as a sandwich of β sheets or a bundle of α helices;