Retinoblastoma usually occurs as a sporadic event but in around 10% of cases there is a positive family history due to autosomal dominant inheritance. In these families the penetrance is approximately 80% (= 0.8). A woman with retinoblastoma, whose father and grandfather were also affected, has an unaffected partner with no relevant family history. Which of the following is correct regarding their children?

TLS Online TPP Program

#Question id: 15421

#Unit 5. Developmental Biology

A signal from the inducing cell is necessary for initiating new gene expression in the responding cell. Without the inducing cell, the responding cell is not capable of differentiating in that particular way, phenomena known as:

TLS Online TPP Program

#Question id: 15422

#Unit 5. Developmental Biology

During Vulval induction in C. elegans, the anchor cell secretes, a paracrine factor which receives by VPCs and become vulva. If the anchor cell is destroyed, the VPCs will not form a vulva. This is the example of:

TLS Online TPP Program

#Question id: 15441

#Unit 4. Cell Communication and Cell Signaling

In hermaphrodites, expression of the egl-1 gene in the neurons is repressed by the transcription factor, and deletion of that causes these neurons to undergo apoptosis;

TLS Online TPP Program

#Question id: 15442

#Unit 4. Cell Communication and Cell Signaling

XIAP, one member of a family of inhibitor of apoptosis proteins (IAPs), provides another way to restrain both initiator and effector caspases; Find out the INCORRECT statements about this inhibitor-

TLS Online TPP Program

#Question id: 15443

#Unit 4. Cell Communication and Cell Signaling

The caspases have which amino acid residues in their catalytic site and what is the cleavage site of these effector proteases;

TLS Online TPP Program

#Question id: 15444

#Unit 4. Cell Communication and Cell Signaling

Which is the Inhibitor of apoptosis proteins (IAPs) because of inhibition of XIAP it not able to bind with caspases, and retain in the cytosol;