Practice Questions

TLS Online TPP Program

#Question id: 12492

A young man with phenylketonuria, who was successfully treated following diagnosis on newborn screening, is planning to start a family with his healthy, unaffected, and unrelated partner, who has no family history of phenylketonuria . Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10 000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

#Part-A Aptitude & General Biotechnology

The probability that his partner is a carrier is 1 in 100.
The probability that the man will transmit a mutant allele to his first child is 1 in 2.
The probability that his partner will transmit a mutant allele to their first child is 1 in 50.
The probability that their first child will be affected is 1 in 100.

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TLS Online TPP Program

#Question id: 14151

#Part-B Specialized Branches in Biotechnology

Which of the following statement is true?

A) PAM matrices are derived from an evolutionary model whereas the BLOSUM matrices consist of entirely direct observations.

B) Because of BLOSUM matrices have less evolutionary meaning that is why the PAM matrices are used most often for reconstructing phylogenetic trees.

C) BLOSUM matrices are entirely derived from local sequence alignments of conserved sequence blocks, whereas the PAM matrix is based on the global alignment of full-length sequences.

D) BLOSUM matrices are more advantageous in searching databases and finding conserved domains in proteins.

TLS Online TPP Program

#Question id: 14151

#Part-A Aptitude & General Biotechnology

Which of the following statement is true?

A) PAM matrices are derived from an evolutionary model whereas the BLOSUM matrices consist of entirely direct observations.

B) Because of BLOSUM matrices have less evolutionary meaning that is why the PAM matrices are used most often for reconstructing phylogenetic trees.

C) BLOSUM matrices are entirely derived from local sequence alignments of conserved sequence blocks, whereas the PAM matrix is based on the global alignment of full-length sequences.

D) BLOSUM matrices are more advantageous in searching databases and finding conserved domains in proteins.

TLS Online TPP Program

#Question id: 14152

#Part-B Specialized Branches in Biotechnology

The statistical analysis of alignment scores is much better understood for ________ than for _______

TLS Online TPP Program

#Question id: 14152

#Part-A Aptitude & General Biotechnology

The statistical analysis of alignment scores is much better understood for ________ than for _______

TLS Online TPP Program

#Question id: 14153

#Part-B Specialized Branches in Biotechnology

Dynamic programming is an example of

TLS Online TPP Program

#Question id: 14153

#Part-A Aptitude & General Biotechnology

Dynamic programming is an example of