BAFF-R expression is first detected in T1 B cells and increases steadily there after.

Signaling through the BAFF/BAFF-R axis promotes survival of transitional B cells by inducing the synthesis of anti-apoptotic factors such as Bcl-2, Bcl-xl, and Mcl-1

TLS Online TPP Program

#Id: 8167

#Section 3: Genetics, Cellular and Molecular Biology

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 9175

#Section 3: Genetics, Cellular and Molecular Biology

Amount of change in allelic frequency due to migration

m= proportional of migratory individual in  recipient population

qI – frequency of allele in source population  

qII – frequency of allele in recipient population

TLS Online TPP Program

#Id: 8193

#Section 3: Genetics, Cellular and Molecular Biology

Pex5 forms a multimeric complex with the Pex14 receptor located on the peroxisomal membrane. 

TLS Online TPP Program

#Id: 8038

#Section 2: General Biology

His ionisation series

1------pK1-----pKr--------pKr------14

TLS Online TPP Program

#Id: 10336

#Section 2: General Biology

They are pAPCs

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Cause humoral immunity or antibodies mediated immunity