Kinesin-1 

is regulated by a 

head-to-tail interaction

TLS Online TPP Program

#Id: 8621

#Section 3: Genetics, Cellular and Molecular Biology

The Cip/Kip family members bind to cyclin-bound CDKs and block the activity of cyclin D-, E-, A-, and B-containing complexes.

TLS Online TPP Program

#Id: 8875

#Section 3: Genetics, Cellular and Molecular Biology

Pin1 and Plk1 modify and phosphorylate Cdc25C to stimulate its phosphatase activity

TLS Online TPP Program

#Id: 8226

#Section 3: Genetics, Cellular and Molecular Biology

I-cell disease

• almost all of the hydrolytic enzymes are missing from the lysosomes of many cell types.

• mis-sorting has been traced to a defective or missing GlcNAc phosphotransferase.

TLS Online TPP Program

#Id: 9162

#Section 3: Genetics, Cellular and Molecular Biology

A recessive allele (a) that causes a genetic disease has a frequency (q) of 0.01. If the population mates randomly (F = 0), the frequency of individuals affected by the disease (aa) will be q = 0.01 = 0.0001.

However, if F = 0.25 expected frequency of the aa is .0026.

TLS Online TPP Program

#Id: 8363

#Section 3: Genetics, Cellular and Molecular Biology

Myosins have 

Motor head domain

Lever-arm neck domain

Cargo-binding tail domain