TLS Online TPP Program

#Id: 8319

#Section 3: Genetics, Cellular and Molecular Biology

Nucleation phase 

Lag period (Time taken for nucleation) Rate-limiting Step.

TLS Online TPP Program

#Id: 8535

#Section 3: Genetics, Cellular and Molecular Biology

Augmin

an 8-subunit protein complex that binds to sites along the microtubule and recruits γ-TuRC, which nucleates a new microtubule to form a microtubule branch.

TLS Online TPP Program

#Id: 9192

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8167

#Section 3: Genetics, Cellular and Molecular Biology

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 8874

#Section 3: Genetics, Cellular and Molecular Biology

Initial pool of active cyclin B-CDK1 phosphorylates Cdc25C, this recruits Pin1 and Plk1, which recognize Cdc25C through their phospho-binding domains.