Suppose the major solutes in intact lysosomes are KCl (~0.1 M) and NaCl (~0.03 M). When isolating lysosomes, what concentration of sucrose is required in the extracting solution at room temperature (25 °C) to prevent swelling and lysis?

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#Question id: 3648

#Section 3: Genetics, Cellular and Molecular Biology

The initiation of DNA replication within a replicon always occurs at a fixed point known as:

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#Question id: 3650

#Section 3: Genetics, Cellular and Molecular Biology

Which of the following is true for the most important form of DNA damage which produces pyrimidine dimers from adjacent pyrimidine bases?

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#Question id: 3651

#Section 3: Genetics, Cellular and Molecular Biology

__________________is spontaneous hydrolytic reaction that involves cleavage of the N-glycosylic bond between N-9 of the purine bases A and G and C-1 of the deoxyribose sugar and hence loss of purine bases from the DNA.

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#Question id: 3652

#Section 3: Genetics, Cellular and Molecular Biology

Alkylating agents are electrophilic chemicals which readily add alkyl groups to various positions on nucleic acids. A common example is:

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#Question id: 3654

#Section 3: Genetics, Cellular and Molecular Biology

Cleavage of the cyclobutane ring of pyrimidine dimers by ______________ restores the original DNA structure.

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#Question id: 3655

#Section 3: Genetics, Cellular and Molecular Biology

The mismatched base is removed from the daughter strand of DNA by: