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TLS Online TPP Program

#Question id: 12908

Which statement is incorrect about CRISPR?

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology
  1. It  was first identified as an adaptive immunity pathway in prokaryotes providing resistance to bacteriophage and analogous to the RNA interference process found in eukaryotes. 
  2. It does not utilize double-stranded sequence-specific breaks and does not  repair using HDR via homologous recombination.
  3. The system consists of two parts, a short synthetic guide RNA ( gRNA) and a nonspecific double-stranded endonuclease termed Cas9. 
  4. It is also possible to program Cas9 with multiple guide RNAs to allow multiplex site-specific editing for designing large deletions, inversions and translocations.
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TLS Online TPP Program

#Question id: 14132

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

The most widely used program for multiple sequence alignment is
TLS Online TPP Program

#Question id: 14133

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

The study of evolutionary relationships is known as
TLS Online TPP Program

#Question id: 14134

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

PAM stands for ___
TLS Online TPP Program

#Question id: 14135

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

Which of the following statement is correct about PAM matrix? 
TLS Online TPP Program

#Question id: 14136

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

Which of the following statement is incorrect about global alignment? 
(A) Global alignment is based on the Needleman–Wunsch algorithm.
(B) In Global alignment algorithm, an optimal alignment is obtained over the entire lengths of the two sequences.
(C) It is only suitable for aligning two closely related sequences that are of the same length.
(D) GAP is a web-based pairwise global alignment program.
TLS Online TPP Program

#Question id: 14137

#Section 7: Recombinant DNA technology and Other Tools in Biotechnology

Consider the following alignment of two DNA sequences:
                            AGTAAC
                            AA_ _AC

Assuming an affine gap scoring scheme of an identity matrix for substitution, a gap initiation penalty of 1 and a gap extension penalty of 0.1, the score of the alignment is _________