Inbreeding coefficient (F)

Probability that an individual has two identical alleles for a given gene. Inbreeding coefficients can range from 0 to 1.

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During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

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During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

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G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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