Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

TLS Online TPP Program

#Id: 8897

#XL - T Zoology

Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

TLS Online TPP Program

#Id: 10039

#XL - T Zoology

Activated IRAK1/2, binds TRAF6, an E3 ubiquitin ligase, to the signalsome, and promotes the formation of an extended 2-D lattice formed by TRAF6-TRAF6 interactions.

TLS Online TPP Program

#Id: 10040

#XL - T Zoology

TRAF6 catalyzes synthesis of long K-63-linked polyubiquitin chains that are covalently linked to TRAF6 itself.

TLS Online TPP Program

#Id: 10041

#XL - T Zoology

Rather than degradation, poly-K63 ubiquitin chains act as scaffolds that bind proteins that have a poly-K63 ubiquitin-binding domain

TLS Online TPP Program

#Id: 10042

#XL - T Zoology

Poly-K63 ubiquitin-binding domain containing proteins:

Protein kinase TAK1

NEMO subunit of the I-κB kinase

TLS Online TPP Program

#Id: 10043

#XL - T Zoology

Poly-K63 ubiquitin chain brings TAK1 kinase and β subunit of I-κB

kinase, into close proximity so that TAK1 can phosphorylate and activate I-κB kinase

TLS Online TPP Program

#Id: 10044

#XL - T Zoology

In Notch/Delta pathway, 

signaling molecule is Delta, an integral membrane protein bound to the surface of the signaling cell.