The Mad1-Mad2 complex bound to a kinetochore adopts the active closed form (Mad2-C) and has the ability to convert inactive open Mad2 (Mad2-O) in the cytoplasm into active closed Mad2 is able to inhibit APC/Ccdc²⁰

TLS Online TPP Program

#Id: 1341

#XL - T Zoology

HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

TLS Online TPP Program

#Id: 1342

#XL - T Zoology

HER3 lacks a functional kinase domain

TLS Online TPP Program

#Id: 1343

#XL - T Zoology

RAS is a small monomeric G-proteins.

TLS Online TPP Program

#Id: 1344

#XL - T Zoology

RAS is connected to the membrane by a prenylated (lipid) tail.

TLS Online TPP Program

#Id: 1345

#XL - T Zoology

All Ras have the CAAX motifs at the C-terminus.

TLS Online TPP Program

#Id: 1346

#XL - T Zoology

Post-translational modifications of the CAAX motifs determine the subcellular localization and correct biological function of Ras proteins.