TLS Online TPP Program

#Id: 10011

#XL - T Zoology

Smo has seven TM α helices, is a member of the GPCR superfamily, and is related in sequence to the Fz.

TLS Online TPP Program

#Id: 10012

#XL - T Zoology

Ptc contains 12 TM α helices and structurally similar

to the Niemann-Pick C1 protein, a cholesterol transporting member of the ABC superfamily

TLS Online TPP Program

#Id: 10013

#XL - T Zoology

In the absence of Hh,

Ptc inhibits Smoothened and then degraded in proteasomes

TLS Online TPP Program

#Id: 10014

#XL - T Zoology

Transcription Factor

zinc-finger transcription factor Cubitis interruptus

TLS Online TPP Program

#Id: 10015

#XL - T Zoology

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 10016

#XL - T Zoology

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).