Perception of MAMPs or DAMPs by cell surface PRRs is called Pathogen Triggered Immunity

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APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

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Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

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Mutating or deleting the destruction box in mitotic cyclins prevented their ubiquitination and blocked cells from exiting mitosis.

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At the metaphase to anaphase transition, APC/C bound to Cdc20 targets cyclins A /B and securin for degradation.

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During late anaphase, telophase and G1, APC/C bound to Cdh1 targets B type cyclins and geminin for degradation.

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