Inflammation

Tissue response to infection or damage which serves to eliminate

Classic signs of acute inflammation are heat (calore), pain (dolore), redness (rubor), swelling (tumor), and loss of function (functio laesa).

TLS Online TPP Program

#Id: 8916

#XL - T Zoology

Cytokinesis

With the exception of higher plants, the division of the cell is brought about by a contractile ring made of actin and myosin

TLS Online TPP Program

#Id: 8917

#XL - T Zoology

TLS Online TPP Program

#Id: 8918

#XL - T Zoology

Centralspindlin is a heterotetramer composed of two copies of the kinesin-6 motor protein MKLP1 and a dimer of a Rho GAP

TLS Online TPP Program

#Id: 8919

#XL - T Zoology

MKLP1 is inhibited by 14-3-3 to ensures that the spindle midzone microtubules do not compact until the end of anaphase

TLS Online TPP Program

#Id: 8920

#XL - T Zoology

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.

TLS Online TPP Program

#Id: 8921

#XL - T Zoology

At the same time, Plk1 phosphorylates the Rho-GAP component, to form an active Centralspindlin-Ect2 complex.