Leishmaniasis

Leishmania is a flagellated protozoan that lives in the phagosomes of macrophages and is transmitted by sand flies.

TLS Online TPP Program

#Id: 9679

#XL - T Zoology

The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.

TLS Online TPP Program

#Id: 9680

#XL - T Zoology

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanines is constitutively active

TLS Online TPP Program

#Id: 9681

#XL - T Zoology

PI-3 kinase signaling pathway is terminated by

PTEN phosphatase, which hydrolyzes the 3-phosphate

in PI 3-phosphates.

TLS Online TPP Program

#Id: 9682

#XL - T Zoology

PTEN can remove phosphate groups attached to serine,

threonine, and tyrosine residues in proteins, its ability to

remove the 3-phosphate from PI(3,4,5)P3 is its major function in cells.

TLS Online TPP Program

#Id: 9683

#XL - T Zoology

Loss of the PTEN protein contributes to the uncontrolled growth of cells.

TLS Online TPP Program

#Id: 9684

#XL - T Zoology

Insulin receptor leads to the activation of PKB