A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 8336

#Unit 2. Cellular Organization

Actin filament treadmilling is accelerated by:

Profilin and Cofilin

TLS Online TPP Program

#Id: 8337

#Unit 2. Cellular Organization

Profilin – G-actin nucleotide exchange (ADP to ATP) 

Cofilin – F-actin disassembly

Thymosin B-4 – G-actin monomer sequestering

TLS Online TPP Program

#Id: 8338

#Unit 2. Cellular Organization

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.

TLS Online TPP Program

#Id: 8339

#Unit 2. Cellular Organization

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end

TLS Online TPP Program

#Id: 8340

#Unit 2. Cellular Organization

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.

TLS Online TPP Program

#Id: 8341

#Unit 2. Cellular Organization

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks