Dissociation of cytosolic complex leads to the stabilization of the full-length Ci, which moves into the

nucleus, displaces the repressor Ci75 from the promoter of target genes, and induces expression of target genes.

TLS Online TPP Program

#Id: 1025

#Unit 5. Developmental Biology

In mammals, Noggin (antagonist of BMP) is expressed in the notochord and neural folds.

TLS Online TPP Program

#Id: 1026

#Unit 5. Developmental Biology

Neural plate formation follow the principle of development:  often the signals promoting the specification of one cell type also block the specification of an alternative cell type.

TLS Online TPP Program

#Id: 1027

#Unit 5. Developmental Biology

The cells of the neural plate expresses:  Sox family of transcription factors (Sox1, 2, and 3)

TLS Online TPP Program

#Id: 1028

#Unit 5. Developmental Biology

Sox family of transcription factors

Inhibit the formation of epidermis and neural crest by blocking the transcription and signaling of BMPs

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#Id: 1029

#Unit 5. Developmental Biology

There are two principal modes of neurulation: 

1. Primary neurulation

2. Secondary neurulation

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#Id: 1030

#Unit 5. Developmental Biology

In primary neurulation, 

cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate into the body, and separate from the surface ectoderm to form an underlying hollow tube.