Three major RNA targets to which the female-specific Sxl transcript binds: 

Pre-mRNA of Sxl itself

msl2 gene

pre-mRNA of transformer (tra)

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#Id: 1271

#Unit 7. System Physiology – Animal

The zona glomerulosa is controlled via; Renin-angiotensin-aldosterone system. 

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#Id: 1272

#Unit 7. System Physiology – Animal

Aldosterone has three actions on the late distal tubule and collecting ducts of the kidney: 

Increases Na+ reabsorption

Increases K+ secretion

Increases H+ secretion

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#Id: 1273

#Unit 7. System Physiology – Animal

ACTH stimulates the synthesis and secretion of cortisol by the activation of adenylyl cyclase via Gs.

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#Id: 1274

#Unit 7. System Physiology – Animal

Angiotensin II stimulates the synthesis and secretion of aldosterone by the activation of phospholipase C via Gq. 

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#Id: 1275

#Unit 7. System Physiology – Animal

Important effect of cortisol, Decrease translocation of GLUT4 to the cell membrane.

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#Id: 1276

#Unit 7. System Physiology – Animal

Cortisol induces the synthesis of lipocortin, an inhibitor of the enzyme PLA2.