Transitional B cells bound for a follicular fate undergo positive and negative selection in the spleen.

TLS Online TPP Program

#Id: 5479

#Unit 7. System Physiology – Animal

Ca2+ uptake into the terminal causes release of the neurotransmitter acetylcholine (ACh), which has been previously synthesized and stored in synaptic vesicles.

TLS Online TPP Program

#Id: 5480

#Unit 7. System Physiology – Animal

ACh is formed from acetyl coenzyme A (acetyl CoA) and choline by the action of the enzyme choline acetyltransferase

TLS Online TPP Program

#Id: 5481

#Unit 7. System Physiology – Animal

ACh diffuses across the synaptic cleft to the postsynaptic Membrane of motor end plate, which contains nicotinic receptors

TLS Online TPP Program

#Id: 5482

#Unit 7. System Physiology – Animal

The nicotinic receptor for ACh is an example of a ligand-gated ion channel

TLS Online TPP Program

#Id: 5483

#Unit 7. System Physiology – Animal

ACh is degraded to choline and acetate by acetylcholinesterase (AChE) on the motor end plate

TLS Online TPP Program

#Id: 5484

#Unit 7. System Physiology – Animal

Approximately 50% of the choline is returned to the presynaptic terminal by Na+-choline cotransport