Nurturing Life Sciences
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#Unit 3. Fundamental Processes
Initiation relies solely upon the interaction between RNA polymerase and duplex DNA, however, the termination event also involves recognition of signals in the transcript by RNA polymerase.
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Rho factor is an essential protein in E. coli that causes transcription termination.
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The rho concentration may be as high as,10% the concentration of RNA polymerase. Rho-independent termination accounts for almost half of E. coli terminators.
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Rho binds to a sequence within the transcript upstream of the site of termination. This sequence is called a rut site (an acronym for rho utilization).