Haploinsufficiency- One copy of the gene is missing, a mutant phenotype is produced.

TLS Online TPP Program

#Id: 9094

#Unit 4. Cell Communication and Cell Signaling

Phospholipase C cleaves a phospholipid known as PI(4,5) P2, generating two second messengers: 

diffusible IP3 and membrane-bound DAG

TLS Online TPP Program

#Id: 10399

#Unit 4. Cell Communication and Cell Signaling

Loss-of-function mutations:

1. A deletion of all or part of a gene.

2. A point mutation in the coding sequence that introduce a stop codon or a frameshift.

TLS Online TPP Program

#Id: 3973

#Unit 7. System Physiology – Animal

The action potential spreads throughout the myocardium in the following sequence: SA node  Atrial internodal tracts and atria  AV node  Bundle of His  Purkinje system  Ventricles

TLS Online TPP Program

#Id: 10221

#Unit 6. System Physiology – Plant

KNOX gene expression increases cytokinin levels in the shoot apical meristem by upregulating the cytokinin biosynthetic gene ISOPENTENYL TRANSFERASE7 (IPT7)

TLS Online TPP Program

#Id: 6490

#Unit 3. Fundamental Processes

Strikingly, a number of TAFs resemble histones: nine of 14 TAPs contain a histone fold domain, though in most cases the TAFs lack the residues of this domain that are responsible for DNA binding.