On the lagging strand a stretch of single-stranded parental DNA must beexposed, and then a segment is synthesized in the reverse direction (relative to fork movement).

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#Unit 5. Developmental Biology

Autonomous Specification

Produces "mosaic" ("determinative") development 

Cells cannot change fate if a blastomere is lost

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#Unit 5. Developmental Biology

In Autonomous Specification, 

Cytoplasmic determinants are apportioned to different blastomeres of the early embryo.

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#Id: 95

#Unit 5. Developmental Biology

Cytoplasmic Determinants

Blastomeres of the early embryo are apportioned a set of critical determination factors within the egg cytoplasm that determine cell fate

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#Unit 5. Developmental Biology

Cytoplasmic Determinants are molecules, often transcription factors that regulate gene expression that directs the cell along a particular path of maturation.

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#Unit 5. Developmental Biology

Conditional specification is the process by which cells achieve their respective fates by interacting with other cells.

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#Id: 98

#Unit 5. Developmental Biology

In conditional specification the array of interactions it has with its neighbors, which may include: 

cell-to-cell contacts (juxtacrine factors)

secreted signals (paracrine factors)

physical properties of its local environment (mechanical stress)