Eukaryotic cells also repair mismatches and do so using homologs to MutS (called MSH proteins for “MutS homologs”) and MutL (called MLH and PMS

TLS Online TPP Program

#Id: 8580

#Unit 2. Cellular Organization

In humans, three genes encode lamins: 

Lamins A and C (alternatively spliced gene) 

Lamins B1 and B2

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#Unit 2. Cellular Organization

B-type lamins - expressed in essentially all cells (primordial lamin proteins)

lamins A and C - developmentally regulated

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#Unit 2. Cellular Organization

Lamins B are post-translationally prenylated, which helps them associate with the inner nuclear envelope membrane.

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#Id: 8583

#Unit 2. Cellular Organization

Lamins 

contribute to genome organization as well as to the rigidity of the nucleus through linkages to the

cytoskeleton involving proteins with SUN and KASH domains

TLS Online TPP Program

#Id: 8584

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8585

#Unit 2. Cellular Organization

Emerin

lamin-binding membrane protein of the inner nuclear envelope