Many genes are arranged along the chromosomes in groups of related genes. These groups are called gene clusters. Examples of gene clusters are the globin gene family.

TLS Online TPP Program

#Id: 2387

#Unit 3. Fundamental Processes

Alternative splicing is often associated with weak splice sites.

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#Id: 2388

#Unit 3. Fundamental Processes

Specific exonic and intronic sequences can enhance or suppress splice site selection.

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#Id: 2389

#Unit 3. Fundamental Processes

In general, SR proteins bind to exonic splicing enhancers and the hnRNP proteins bind to exonic silencers

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#Id: 2390

#Unit 3. Fundamental Processes

Binding of SR proteins to ESEs promotes or stabilizes U1 binding to the 5’ splice site and U2AF binding to the 3’ splice site.

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#Id: 2391

#Unit 3. Fundamental Processes

The Nova and Fox families of RNA-binding proteins can promote or suppress splice site selection in a context-dependent fashion.

TLS Online TPP Program

#Id: 2392

#Unit 3. Fundamental Processes

Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.