Camptothecin is an inhibitor of eukaryotic type I topoisomerases.

Irinotecan (Campto) and topotecan (Hycamtin)—used to treat colorectal cancer and ovarian cancer.

All these drug's act by trapping the topoisomerase-DNA complex in which the DNA is cleaved, inhibiting religation.

TLS Online TPP Program

#Id: 6871

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 712

#Unit 3. Fundamental Processes

Hda is recruited by DNA Polymerase in previous cycle and it acts to switch off DnaA, preventing a second round of replication.

TLS Online TPP Program

#Id: 5560

#Unit 7. System Physiology – Animal

Medullary collecting duct is permeable to urea, and there are special urea transporters that facilitate urea diffusion across the luminal and basolateral membranes

TLS Online TPP Program

#Id: 5822

#Unit 7. System Physiology – Animal

Angiotensin II stimulates the synthesis and secretion of aldosterone by the activation of phospholipase C via Gq

TLS Online TPP Program

#Id: 6730

#Unit 8. Inheritance Biology