Camptothecin is an inhibitor of eukaryotic type I topoisomerases.

Irinotecan (Campto) and topotecan (Hycamtin)—used to treat colorectal cancer and ovarian cancer.

All these drug's act by trapping the topoisomerase-DNA complex in which the DNA is cleaved, inhibiting religation.

TLS Online TPP Program

#Id: 8144

#Unit 2. Cellular Organization

Vesicle Type- COPI

Transport - cis-Golgi to ER

Coat Proteins – Coatomers

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8145

#Unit 2. Cellular Organization

Vesicle Type- Clathrin

Transport - trans-Golgi to endosome

Coat Proteins – Clathrin + AP1 complexes

                            Clathrin + GGA

Associated GTPase- ARF

TLS Online TPP Program

#Id: 8146

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8147

#Unit 2. Cellular Organization

A clathrin molecule,

called a triskelion, is composed of : 

Three heavy chains

Three light chains

TLS Online TPP Program

#Id: 8148

#Unit 2. Cellular Organization

Depolymerization of the clathrin coat into triskelions  by Cytosolic Hsp70

TLS Online TPP Program

#Id: 8149

#Unit 2. Cellular Organization

ARF and Sar1 similar to Ras