The probability distribution of a statistic, from a particular population, over many random samples is the sampling distribution.

TLS Online TPP Program

#Id: 7929

#Unit 2. Cellular Organization

The ER captures selected proteins from the cytosol as they are being synthesized. These are of two types:

Transmembrane proteins

Water-soluble proteins

TLS Online TPP Program

#Id: 7930

#Unit 2. Cellular Organization

Secretory pathway

pathway of protein trafficking that flows through the ER

TLS Online TPP Program

#Id: 7931

#Unit 2. Cellular Organization

Microsomes

when cells are homogenized, the rough ER breaks up into small closed vesicles with ribosomes on the outside

TLS Online TPP Program

#Id: 7932

#Unit 2. Cellular Organization

Signal sequence

ER targeting sequence, located at the N-terminus of the protein

TLS Online TPP Program

#Id: 7933

#Unit 2. Cellular Organization

Signal sequences

contain one or more positively charged amino acids adjacent to a continuous stretch of 6–12 hydrophobic residues (known as the hydrophobic core)

TLS Online TPP Program

#Id: 7934

#Unit 2. Cellular Organization

The two key components in protein targeting in ER:

Signal recognition particle (SRP)

SRP receptor