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TLS Online TPP Program

#Id: 4860

Hanes plot 

#Unit 1. Molecules and their Interaction Relevant to Biology #Enzyme catalysis #Part B Pointers
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TLS Online TPP Program

#Id: 1548

#Unit 2. Cellular Organization

Nocodazole and colchicine
TLS Online TPP Program

#Id: 1549

#Unit 2. Cellular Organization

Two main families of motor proteins mediate transport along microtubules:

Kinesins 

Dyneins
TLS Online TPP Program

#Id: 1550

#Unit 2. Cellular Organization

Kinesin-1 powers anterograde transport of vesicles down axons toward the (+) ends of microtubules.
TLS Online TPP Program

#Id: 1551

#Unit 2. Cellular Organization

Kinesin-1  (similar to myosin II)
Head domain at the N-terminus of the heavy chain  
Stalk domain forms a long coiled-coil
Tail domain at C-terminus that attaches to cargo
TLS Online TPP Program

#Id: 1552

#Unit 2. Cellular Organization

Kinesin-5 forms tetramers, assembled in a bipolar configuration to interact with two antiparallel microtubules and move toward the (+) ends.
TLS Online TPP Program

#Id: 1553

#Unit 2. Cellular Organization

Kinesin-14 is a C-terminal kinesin & travel toward the microtubule minus end.