TLS Online TPP Program

#Id: 1456

#Unit 4. Cell Communication and Cell Signaling

Heterophilic Binding

A CAM on one cell can directly bind to a different class of CAM on an adjacent cell 

TLS Online TPP Program

#Id: 1457

#Unit 4. Cell Communication and Cell Signaling

CAMs can be broadly distributed along the regions of plasma membranes that contact other cells or clustered in discrete patches or spots called cell junctions.

 

TLS Online TPP Program

#Id: 1458

#Unit 4. Cell Communication and Cell Signaling

The formation of many cell-cell adhesions entails two types of molecular interactions:

1. Trans binding interactions 

2. Cis binding interactions

TLS Online TPP Program

#Id: 1459

#Unit 4. Cell Communication and Cell Signaling

In trans interactions (intercellular or adhesive interactions) CAMs on one cell bind to the CAMs on an adjacent cell. 

TLS Online TPP Program

#Id: 1460

#Unit 4. Cell Communication and Cell Signaling

In cis interactions (intracellular or lateral interactions) monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane.

TLS Online TPP Program

#Id: 1461

#Unit 4. Cell Communication and Cell Signaling

CAMs fall into one of four major families: 

• Cadherins

• Immunoglobulin (Ig) superfamily

• Integrins

• Selectins