By counting the number of sites to which ORC binds, we can estimate that there are about 400 origins of replication in the yeast genome. This means that the average length of a replicon is 35,000 bp.

TLS Online TPP Program

#Id: 697

#Unit 3. Fundamental Processes

Substitutions occurs when Proofreading fails

TLS Online TPP Program

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#Unit 3. Fundamental Processes

Frameshifts occurs when Processivity fails

TLS Online TPP Program

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#Unit 3. Fundamental Processes

Frameshifts normally occurs homopolymeric sequences as long sequence of dTn:dAn

TLS Online TPP Program

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#Unit 3. Fundamental Processes

As a general rule, increased processivity reduces the likelihood of slippage at long sequence of dTn:dAn or frameshift mutation 

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#Unit 3. Fundamental Processes

Which of the polymerase can recognise A-A complimentary base pairs as normal

1. I 2. II 3. III     4. IV 

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#Unit 3. Fundamental Processes

The replicase activity of DNA polymerase III was originally discovered by a conditional lethal mutation in the dnaE locus, which codes for the 130 kD, a subunit that possesses the DNA synthetic activity.