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TLS Online TPP Program

#Id: 6395

Major enzyme is Tryptophan Synthase whose activity is reduced when trp concentration is high

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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TLS Online TPP Program

#Id: 3234

#Unit 4. Cell Communication and Cell Signaling

Noncoding RNAs (RNAs that do not encode proteins),
especially micro-RNAs (miRNAs), play a critical role in tumorigenesis.
TLS Online TPP Program

#Id: 3235

#Unit 4. Cell Communication and Cell Signaling

Let-7 miRNAs act like tumor-suppressors down-regulate the translation of Ras & targets oncogenic transcription factor MYC
TLS Online TPP Program

#Id: 3237

#Unit 4. Cell Communication and Cell Signaling

miR-15-a and miR-16-1 act like tumor-suppressors;
they normally inhibit B cell proliferation
TLS Online TPP Program

#Id: 3239

#Unit 4. Cell Communication and Cell Signaling

miR-21 targets tumor-suppressor gene PTEN phosphatase
TLS Online TPP Program

#Id: 10390

#Unit 4. Cell Communication and Cell Signaling

Four stages of the evolutionary progression of cancer:

Initiation→Cancer progression → Evasion of cancer cell elimination  → Tumor growth and dispersal 
TLS Online TPP Program

#Id: 10391

#Unit 4. Cell Communication and Cell Signaling

Cancer cells 
acquire a drive to proliferate 
does not require an external inducing signal
fail to sense signals that restrict cell division
survive when they should die