#Id: 6870
#Unit 3. Fundamental Processes
Rap1 recruits Sir4 on acetylated histones, then recruits both its binding partner Sir3 and the HDAC Sir2.
Sir3 and Sir4 then interact directly with histones H3 and H4. Once Sir3 and Sir4 have bound to histones H3 and H4,
Sir2 deacetylates histones
Sir2-dependent deacetylation represses transcription.