Nurturing Life Sciences
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#Unit 3. Fundamental Processes
The M C M 2 - 7 proteins form a six-member ring-shaped complex around DNA. MCM 2, 3, 5 are regulatory, while MCM4,6,7 have helicase activity.
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When initiation occurs, Cdc6 and Cdtl are displaced, returning the origin to the state of the postreplication complex, which contains only ORC.
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in mammalian cells, Cdt1 is targeted for degradation by the action of a protein complex that is recruited to the origin of replication by PCNA, the eukaryotic counterpart of the bacterial beta-clamp.
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The MCM proteins, once activated, are required for elongation as well as for initiation.