The nucleoporins are of three types: 

a. Structural nucleoporins

b. Membrane nucleoporins

c. FG-nucleoporins

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#Unit 7. System Physiology – Animal

Mesangial cells are contractile and play a role in the regulation of glomerular filtration. 

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#Unit 7. System Physiology – Animal

Glomerular filtration barrier is selective in determining which molecules will filter, based on their,

1. Size 

2. Electrical charge

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#Unit 7. System Physiology – Animal

Endothelium & epithelial cells, effectively prevents filtration of plasma proteins, because of strong negative electrical charges (associated with the proteoglycans).

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#Unit 7. System Physiology – Animal

Negatively charged large molecules are filtered less easily than positively charged molecules of equal molecular size.

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#Unit 7. System Physiology – Animal

Minimal Change Nephropathy 

negative charges on the basement membrane are lost

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#Unit 7. System Physiology – Animal

Factors governing filtration across the glomerular capillaries:

1. Size of the capillary bed

2. Permeability of the capillaries

3. Hydrostatic and osmotic pressure gradients across the capillary wall