formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8586

#Unit 2. Cellular Organization

Inside the nucleus, SUN proteins bind to the nuclear lamina or chromosomes.

TLS Online TPP Program

#Id: 8587

#Unit 2. Cellular Organization

In the cytoplasm, KASH proteins can bind directly to microfilaments and indirectly to microtubules and Ifs through association with motor proteins and plakins, respectively.

TLS Online TPP Program

#Id: 8588

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8589

#Unit 2. Cellular Organization

Lamins are reversibly disassembled by phosphorylation during mitosis

TLS Online TPP Program

#Id: 8590

#Unit 2. Cellular Organization

Mitotic CDKs drive phosphorylation of lamins A, B, and C results in disassembly of the intermediate filament lattice into lamin dimers.

TLS Online TPP Program

#Id: 8591

#Unit 2. Cellular Organization

Due to C-terminal prenylation of lamin B, 

lamin B dimers remain associated with the nuclear

membrane