TLS Online TPP Program

#Id: 1484

#Unit 4. Cell Communication and Cell Signaling

Monomers and dimers of p53, exists in the cytoplasm. 

TLS Online TPP Program

#Id: 1485

#Unit 4. Cell Communication and Cell Signaling

The tetramerized p53 localize in nucleus for transcriptional activation.

TLS Online TPP Program

#Id: 1486

#Unit 4. Cell Communication and Cell Signaling

When DNA is damaged, p53 is tetramerized and accumulates rapidly.

TLS Online TPP Program

#Id: 1487

#Unit 4. Cell Communication and Cell Signaling

The tumor suppressor proteins p53 and Rb act as guardians of the cell cycle.

TLS Online TPP Program

#Id: 1488

#Unit 4. Cell Communication and Cell Signaling

The DNA damage checkpoint controlled by p53.

TLS Online TPP Program

#Id: 1489

#Unit 4. Cell Communication and Cell Signaling

p53,  Induces the expression of CDK inhibitor p21 Induces apoptosis